Karyorrhexis

Karyorrhexis (from Greek κάρυον karyon 'kernel, seed, nucleus' and ῥῆξις rhexis 'bursting') is the destructive fragmentation of the nucleus of a dying cell^[1] whereby its chromatin is distributed irregularly throughout the cytoplasm.^[2] It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis. ^{[citation needed]}

In apoptosis, the cleavage of DNA is done by Ca²⁺ and Mg²⁺ -dependent endonucleases. ^{[citation needed]}

Morphological characteristics of pyknosis and other forms of nuclear destruction.
Microscopy of an apoptotic neutrophil with nuclear fragmentation (H&E stain)

References

^ Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. Bibcode:1999Natur.401..127Z. doi:10.1038/43591. PMID 10490018. S2CID 36673000.
^ Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. Retrieved 11 November 2017.

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[zamzami-1] Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. Bibcode:1999Natur.401..127Z. doi:10.1038/43591. PMID 10490018. S2CID 36673000.

[2] Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. Retrieved 11 November 2017.

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v t e Pathology
Principles of pathology	Disease Infection Neoplasia Cause Pathogenesis Hemodynamics Ischemia Inflammation Cell damage Wound healing Cellular adaptation Atrophy Hypertrophy Hyperplasia Dysplasia Metaplasia Squamous Glandular Cell death Necrosis Coagulative necrosis Liquefactive necrosis Gangrenous necrosis Caseous necrosis Fat necrosis Fibrinoid necrosis Myocytolysis Programmed cell death Apoptosis Pyknosis Karyorrhexis Karyolysis Accumulations pigment Hemosiderin Lipochrome/Lipofuscin Melanin Steatosis
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See also

References